Hyaluronic Acid (HA) ndi molekyulu yamatsenga yomwe imagwiritsidwa ntchito kwambiri m'minda yakukongolandi mankhwala.Kutulukira kwake ndi kakulidwe kake kamakhala ndi kuyesetsa kosalekeza komanso luso laukadaulo la asayansi.Nkhaniyi ifotokoza za magwero, mbiri yakale komanso chitukuko chaasidi hyaluronicm'zaka za m'ma 1900, zikuwulula ulendo wodabwitsa wa molekyulu imeneyi.

Zomwe zapezeka:

Kutulukira koyambirira kwambiri kunali mu 1934, pamene Karl Meyer, dokotala wa maso pa yunivesite ya Columbia, ndi womuthandizira wake John Palmer anapatula polysaccharide ya molekyulu yokhala ndi uronic acid ndi shuga wa amino kuchokera ku thupi la vitreous la maso a bovine.Kupezeka uku ndi chizindikiro cholowa chovomerezeka chaasidi hyaluronicmu asayansi 'm'mphepete.Popeza chigawo chokhala ndi uronic acid chimachotsedwa mu thupi la vitreous, chinthucho chimatchedwa dzinaHyaluronic acid, yomwe imadziwikanso kutiasidi hyaluronic.Kenako patangopita nthawi yochepa kuchokera mu 1948 mpaka 1951, akatswiri a zamankhwala angapo anayamba kuphunzira kapangidwe ka asidi hyaluronic.

Nyengo yatsopano ya njira zochotsera:

M'zaka za m'ma 1960, ndi kupita patsogolo kwa sayansi ndi luso lamakono, ofufuza anayamba kugwiritsa ntchito njira zochotsa minofu kuti apange hyaluronic acid.Njirayi imaphatikizapo kuchotsa asidi wa hyaluronic ku minofu ya nyama, koma inali yokwera mtengo ndipo sinalandire chisamaliro chochuluka ndi ntchito panthawiyo.Komabe, kukula kwa njira imeneyi kwalimbikitsa kufufuza kwina kwa asidi hyaluronic m'munda wa mankhwala ndi biology, kuyika maziko a ntchito yake yaikulu m'tsogolomu.

Njira zatsopano zowotchera:

Kusintha kwenikweni kunachitika m'zaka za m'ma 1980, pamene Shiseido ya ku Japan inayamba kugwiritsa ntchito fermentation kupanga hyaluronic acid.Izi nzeru kupanga njira osati bwino chiyero chaasidi hyaluronic, komanso kumawonjezera kwambiri zokolola zake, ndikupangitsa kukhala biomaterial yotchuka.The kumayambiriro nayonso mphamvu njira anawonjezera ntchito minda asidi hyaluronic, kuphatikizapokukongola, mankhwala ndi machitidwe operekera mankhwala.

Nthawi yamtengo wapatali ya kukongola ndi mankhwala:

Pamene teknoloji yopanga hyaluronic acid ikupitilirabe bwino, m'zaka za zana la 21, pang'onopang'ono yakhala nyenyezi.chopangiram’minda ya kukongola ndi mankhwala.Mu zodzoladzola, asidi hyaluronic chimagwiritsidwa ntchito monga filler kusalaza makwinya ndi kuonjezerakhungu elasticity.Mankhwala, asidi hyaluronic amagwiritsidwa ntchito m'madera monga nyamakazi, opaleshoni ya maso, ndi machiritso a bala, kusonyeza zotsatira zabwino zachipatala.

Pomaliza:

Ulendo wa mbiri yakale wa asidi hyaluronic ndi wodabwitsa, kuyambira pomwe adapeza koyamba mpaka pakupanga njira zochotsa mpaka pakuyambitsa njira zowotchera, asidi a hyaluronic akupitiliza kusinthika kuti apereke mayankho apamwamba kwa anthu.zodzikongoletserandi zosowa zachipatala.Molekyu yodabwitsayi idzapitiriza kugwira ntchito yofunika kwambiri pa kafukufuku wa sayansi ndi zamankhwala, ndikuyika maziko olimba a zatsopano ndi chitukuko chamtsogolo.